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Also called: Renal disease

Your kidneys are two bean-shaped organs, each about the size of your fists. They are located near the middle of your back, just below the rib cage. Inside each kidney about a million tiny structures called nephrons filter blood. They remove waste products and extra water, which become urine. The urine flows through tubes called ureters to your bladder, which stores the urine until you go to the bathroom.

Damage to the nephrons results in kidney disease. This damage may leave kidneys unable to remove wastes. Usually the damage occurs slowly over years. There are no obvious symptoms, so you don't know it is happening.

Many things can cause kidney disease. You are at risk if you have

  • Diabetes
  • High blood pressure
  • A close family member with kidney disease
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Your doctor can run tests to find out if you have kidney disease. If your kidneys fail completely, a kidney transplant or dialysis can replace the work your kidneys normally do.
 
 
 
Also called: Hypernephroma, Renal adenocarcinoma, Renal cell cancer

You have two kidneys. They are fist-sized organs on either side of your backbone above your waist. The tubes inside filter and clean your blood, taking out waste products and making urine. Kidney cancer forms in the lining of tiny tubes inside your kidneys. It happens most often in people over 40. Risk factors include smoking, having certain genetic conditions and misusing pain medicines for a long time.

Often, kidney cancer doesn't have early symptoms. However, see your health care provider if you notice

  • Blood in your urine
  • A lump in your abdomen
  • Unexplained weight loss
  • Pain in your side
  • Loss of appetite

Treatment depends on your age, your overall health and how advanced the cancer is. It might include surgery, radiation, chemotherapy or biologic therapy. Biologic therapy boosts your body's own ability to fight cancer.

National Cancer Institute

 
 
 
 
Also called: End-stage renal disease, ESRD, Renal failure

Healthy kidneys clean your blood by removing excess fluid, minerals and wastes. They also make hormones that keep your bones strong and your blood healthy. But if the kidneys are damaged, they don't work properly. Harmful wastes can build up in your body. Your blood pressure may rise. Your body may retain excess fluid and not make enough red blood cells. This is called kidney failure.

If your kidneys fail, you need treatment to replace the work they normally do. The treatment options are dialysis or a kidney transplant. Each treatment has benefits and drawbacks. No matter which treatment you choose, you'll need to make some changes in your life, including how you eat and plan your activities. But with the help of healthcare providers, family and friends, most people with kidney failure can lead full and active lives.

National Institute of Diabetes and Digestive and Kidney Diseases